Browsing Experimentally Confirmed database

Result: Your query found 50 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
actR
  • BacMet ID: BAC0565
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 194
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actS
  • BacMet ID: BAC0566
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 433
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    cadA/yvgW
  • BacMet ID: BAC0055
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392/26695)(Campylobacter pylori)
  • Location: Plasmids pI258 (S. aureus), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium efflux ATPase, has two domains (phosphatase, aspartyl kinase); Cadmium, zinc and cobalt-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell
  • Length (amino acid): 686
  • Reference: Herrman et al. 1999; Pubmed- 10417643, Nucifera et al. 1989; Pubmed- 2524829, Lee et al. 2001; Pubmed- 11282588

    		• Similar resistance genes in 'BacMet Predicted database'
    cadC
  • BacMet ID: BAC0056
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258 (Staphylococcus aureus)
  • Compound: Cadmium (Cd), Bismuth (Bi), Zinc (Zn), Lead (Pb)
  • Description: Found in cad operon; bind to cad operator/promoter, its a repressor protein in the operon; Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA
  • Length (amino acid): 122
  • Reference: Endo et al. 1995; Pubmed- 7543476

    		• Similar resistance genes in 'BacMet Predicted database'
    cadD
  • BacMet ID: BAC0057
  • Code for: Enzyme
  • Family: CadD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain N315)
  • Location: Plasmid pN315 (Staphylococcus aureus (strain N315)), Plasmid pLUH02 (Staphylococcus aureus (strain ECT-R 2) ), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance permease; These proteins are members of the Cadmium Resistance (CadD) Family. To date, this family of proteins has only been found in Gram-positive bacteria. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, and another staphylococcal protein that has been reported to possibly function in quaternary ammonium ion Export.
  • Length (amino acid): 205
  • Reference: Crupper et al. 1999; Pubmed- 10383976, Kuroda et al. 2001; Pubmed- 11418146

    		• Similar resistance genes in 'BacMet Predicted database'
    cadR
  • BacMet ID: BAC0058
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pECd1 (uncultured bacterium), Chromosome
  • Compound: Cadmium (Cd)
  • Description: Transcriptional regulator CadR; Responsible for cadmium resistance
  • Length (amino acid): 147
  • Reference: Lee et al. 2001; Pubmed- 11282588

    		• Similar resistance genes in 'BacMet Predicted database'
    cadX
  • BacMet ID: BAC0059
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus salivarius
  • Location: Plasmid pLUG10 (Staphylococcus lugdunensis)
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance regulatory protein CadX
  • Length (amino acid): 112
  • Reference: Chen et al. 2008; Pubmed- 18165364

    		• Similar resistance genes in 'BacMet Predicted database'
    czcA
  • BacMet ID: BAC0119
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein; the basic inner membrane transport protein; Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC).
  • Length (amino acid): 1063
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcB
  • BacMet ID: BAC0120
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein CzcB; Membrane fusion protein bridges inner and outer cell membranes (in periplasm); CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
  • Length (amino acid): 520
  • Reference: Nies et al. 1989; Pubmed- 2678100, Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    czcC
  • BacMet ID: BAC0121
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Muter membrane protein; CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt.
  • Length (amino acid): 418
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcD
  • BacMet ID: BAC0122
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transporter gene influence Zn++ and Cd++ resistance; Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter.
  • Length (amino acid): 316
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcE
  • BacMet ID: BAC0123
  • Code for: Binding protein
  • Family: Cation efflux family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: CzcE, involved in Cd(II), Zn(II), Co(II) resistance; copH like protein; Co/Zn/Cd efflux system transmembrane protein
  • Length (amino acid): 133
  • Reference: Zoropogui et al. 2007; Pubmed- 18029263

    		• Similar resistance genes in 'BacMet Predicted database'
    czcP
  • BacMet ID: BAC0124
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cupriavidus metallidurans CH34
  • Location: Plasmid pMOL30 (Cupriavidus metallidurans CH34)
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: P(IB4)-type ATPases; CzcP seemed to enhance metal resistance but relies on the action of the P(IB2)-type ATPases such as zntA, cadA, pbrA etc.
  • Length (amino acid): 829
  • Reference: Scherer et al. 2009; Pubmed- 19602147

    		• Similar resistance genes in 'BacMet Predicted database'
    czcR
  • BacMet ID: BAC0125
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transcriptional activator protein CzcR; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis
  • Length (amino acid): 225
  • Reference: Nies et al. 1992; Pubmed- 1459958

    		• Similar resistance genes in 'BacMet Predicted database'
    czcS
  • BacMet ID: BAC0126
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Sensor protein CzcS; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation.
  • Length (amino acid): 476
  • Reference: Van der Lelie et al. 1997; Pubmed- 9044283

    		• Similar resistance genes in 'BacMet Predicted database'
    cznA
  • BacMet ID: BAC0127
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznA
  • Length (amino acid): 1019
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznB
  • BacMet ID: BAC0128
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznB
  • Length (amino acid): 351
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznC
  • BacMet ID: BAC0129
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel outer membrane efflux protein cznC
  • Length (amino acid): 424
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    czrA
  • BacMet ID: BAC0130
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: A repressor for thr czr operon; part of the czrSRCBA resistance operon
  • Length (amino acid): 1051
  • Reference: Valencia et al. 2013; Pubmed- 23578014; Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    czrB
  • BacMet ID: BAC0131
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: czrB involved in cadmium and zinc resistance; part of the czrSRCBA resistance operon
  • Length (amino acid): 405
  • Reference: Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeF
  • BacMet ID: BAC0132
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Wautersia metallidurans CH34
  • Location: Plasmid pMOL28 (Wautersia metallidurans CH34)
  • Compound: Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34.
  • Length (amino acid): 382
  • Reference: Scherer et al. 2009; Pubmed- 19602147, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbA
  • BacMet ID: BAC0136
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbA subfamily.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Mercury (Hg)
  • Description: Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis
  • Length (amino acid): 208
  • Reference: Rensing et al. 1997; Pubmed- 9098080, Bardwell et al. 1991; Pubmed- 1934062; Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbB
  • BacMet ID: BAC0137
  • Code for: Enzyme
  • Family: DsbB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg)
  • Description: Disulfide oxidoreductase; The dsbB gene codes for a transmembrane protein that is responsible for reoxidizing the periplasmic dsbA-encoded disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA
  • Length (amino acid): 176
  • Reference: Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    fieF/yiip
  • BacMet ID: BAC0167
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.
  • Length (amino acid): 300
  • Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    fpvA
  • BacMet ID: BAC0169
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)
  • Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane
  • Length (amino acid): 815
  • Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567

    		• Similar resistance genes in 'BacMet Predicted database'
    frnE
  • BacMet ID: BAC0170
  • Code for: Enzyme
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Deinococcus radiodurans
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Disulfide Isomerase Chaperone; It is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation; is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation
  • Length (amino acid): 252
  • Reference: Khairnar et al. 2013; Pubmed- 23603741

    		• Similar resistance genes in 'BacMet Predicted database'
    irlR
  • BacMet ID: BAC0197
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Transcriptional activator protein IrlR; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance
  • Length (amino acid): 229
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    irlS
  • BacMet ID: BAC0198
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain, 1 HAMP domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Sensor protein IrlS; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation.
  • Length (amino acid): 464
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    mntA/ytgA
  • BacMet ID: BAC0250
  • Code for: Binding protein
  • Family: Bacterial solute-binding protein 9 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Manganese (Mn), Cadmium (Cd)
  • Description: Manganese-binding lipoprotein MntA; This protein is a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. May be the major manganese uptake system during sporulation
  • Length (amino acid): 306
  • Reference: Hao et al. 1999; Pubmed- 10543781, Que et al. 2000; Pubmed- 10760146

    		• Similar resistance genes in 'BacMet Predicted database'
    mntH/yfeP
  • BacMet ID: BAC0251
  • Code for: Membrane Transporter
  • Family: NRAMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cadmium (Cd), Cobalt (Co), Zinc (Zn)
  • Description: Divalent metal cation transporter MntH; H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.
  • Length (amino acid): 412
  • Reference: Makui et al. 2000; Pubmed- 10712688

    		• Similar resistance genes in 'BacMet Predicted database'
    mrdH
  • BacMet ID: BAC0254
  • Code for: Membrane Transporter
  • Family: NicO family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Membrane protein transpoeter mrdH
  • Length (amino acid): 377
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    nccA
  • BacMet ID: BAC0549
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.
  • Length (amino acid): 1076
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccB
  • BacMet ID: BAC0550
  • Code for: Efflux
  • Family: RND superfamily, Membrane Fusion Protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 397
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccC
  • BacMet ID: BAC0551
  • Code for: Efflux
  • Family: RND superfamily, Outer Membrane factor (OMF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 437
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccH
  • BacMet ID: BAC0555
  • Code for: Regulator
  • Family: Sigma-70 factor family. ECF subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 186
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccN
  • BacMet ID: BAC0554
  • Code for: Membrane Transporter
  • Family: Contains 1 Phospholipid methyltransferase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport.
  • Length (amino acid): 213
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccX
  • BacMet ID: BAC0553
  • Code for: Regulator
  • Family: contains 1 heavy-metal resistance domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 148
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccY
  • BacMet ID: BAC0552
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 95
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nmtR
  • BacMet ID: BAC0281
  • Code for: Regulator
  • Family: ArsR-SmtB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cadmium (Cd), Lead (Pb)
  • Description: Represses transcription of ctpJ/nmtA, by binding to its promoter region
  • Length (amino acid): 120
  • Reference: Cavet et al. 2002; Pubmed- 12163508

    		• Similar resistance genes in 'BacMet Predicted database'
    PA0320
  • BacMet ID: BAC0297
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species
  • Length (amino acid): 116
  • Reference: Fukushima et al. 2012; Pubmed- 22990488

    		• Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

    		• Similar resistance genes in 'BacMet Predicted database'
    ychH
  • BacMet ID: BAC0434
  • Code for: Unknown
  • Family: Contains DUF2583 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Stress protein YchH; response to Hydrogen Peroxide (H2O2), cadmium; plays a role in biofilm formation as well
  • Length (amino acid): 92
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    ygiW
  • BacMet ID: BAC0445
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pMR-1 (Shewanella oneidensis (strain MR-1))
  • Compound: Cadmium (Cd), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Protein YgiW; located in periplasm; responsible for tributyltin (TBT) resistance; response to hydrogen peroxide (H2O2), cadmium ions ; has a role in biofim formation
  • Length (amino acid): 130
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yhcN
  • BacMet ID: BAC0446
  • Code for: Unknown
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer membrane protein YhcN; stress response protein
  • Length (amino acid): 87
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yjaA
  • BacMet ID: BAC0447
  • Code for: Unknown
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress response protein YjaA; a YjaA mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 127
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yodD
  • BacMet ID: BAC0451
  • Code for: Unknown
  • Family: Contains a DUF2525 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress protein YodD; a yodD mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 75
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    zinT/yodA
  • BacMet ID: BAC0457
  • Code for: Binding protein
  • Family: calycin superfamily. ZinT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Metal-binding protein (Cadmium-induced protein) ZinT; Function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn2+ over Cd2+. Contains one high affinity metal binding site, and can bind additional metal ions at other sites; Repressed by Zur
  • Length (amino acid): 216
  • Reference: Stojnev et al. 2007; Pubmed- 17632755

    		• Similar resistance genes in 'BacMet Predicted database'
    zipB
  • BacMet ID: BAC0458
  • Code for: Porter
  • Family: Zrt- and Irt-like Protein (ZIP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: zipB is a selective electrodiffusional channel; facilitates passive zinc uptake driven by zinc concentration gradients that are maintained by cellular zinc homeostasis
  • Length (amino acid): 309
  • Reference: Lin et al. 2010; Pubmed- 20876577

    		• Similar resistance genes in 'BacMet Predicted database'
    zntA/yhhO
  • BacMet ID: BAC0461
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Lead (Pb), Cadmium (Cd), Zinc (Zn)
  • Description: Lead, cadmium, zinc and mercury-transporting ATPase ZntA; Involved in export of lead, cadmium, zinc and mercury; located in inner cell membrane.
  • Length (amino acid): 732
  • Reference: Rensing et al. 1997; Pubmed- 9405611, Beard et al. 1997; Pubmed- 9364914

    		• Similar resistance genes in 'BacMet Predicted database'
    zupT/ygiE
  • BacMet ID: BAC0469
  • Code for: Porter
  • Family: ZIP transporter family, ZupT subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)
  • Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.
  • Length (amino acid): 257
  • Reference: Grass et al. 2005; Pubmed- 15716430

    		• Similar resistance genes in 'BacMet Predicted database'
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